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Simplified metabolism of fluoxetine.

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Simplified metabolism of fluoxetine.

Post  TomDzi on Sun Sep 29, 2013 9:51 am

Hi,
I am writing an IB extended essay on the factors (pH, temperature, concentration of reactants) affecting the rate of metabolism of fluoxetine (secondary amine). The primary metabolic route is via demethylation (by oxydation) but I can't conduct any experiments with it since it is classified drug and moreover an experiment would need a use of an expensive enzyme (CYP2D6). Hence, I'm trying to oxidise another secondary amine to yield formaldehyde and a demetylised primary corresponding amine by using PDC. Here's my two problems:
Does pyridinium dichromate (PDC) oxidise formaldehyde?
Does PDC oxidise the methyl groups in secondary amines only? (or does it oxidise some other groups as well?)
Could you please provide the source for this information?
Thanks a lot Smile
Tomasz

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Re: Simplified metabolism of fluoxetine.

Post  JasonGHerbalExt on Mon Sep 30, 2013 12:39 am

http://www.chemistry.mtu.edu/pages/courses/organic/manuals/2421/Oxidation/Oxidation05.pdf
This may help. Anyway, You still need NMR to testify.

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