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know sth about cis-4-hydroxy-L-proline

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know sth about cis-4-hydroxy-L-proline

Post  sherryfu on Tue Apr 13, 2010 3:51 am

Several structural analogues of proline have been shown to be incorporated into proteins in place of proline.In a study, the effects of two proline analogues, cis-4-Hydroxy-L-prolineand L-azetidine-2-carboxylic acid, on the growth parameters and procollagen production by cultured normal human skin fibroblasts were examined.

Also, a significantly increased fraction of the newly synthesized collagenous peptides was in a dialyzable form, suggesting increased degradation of the nonhelical chains. The rate of translation of collagenous polypeptides and the of preprocollagen messenger RNA activity in the cells were not affected by the analogues. The proline analogues thus appear to inhibit the production of procollagen on the posttranslational level by preventing the polypeptides from folding into a stable triple-helical conformation. The nonhelical polypeptides are then readily susceptible to proteolysis leading to reduced deposition of extracellular collagen fibers. Similar experiments were also performed with fibroblasts cultured from patients with active progressive systemic sclerosis.

The results suggest, Quantitatively and qualitatively comparable inhibition of procollagen production by L-azetidine-2-carboxylic acid was noted with scleroderma cells as with control fibroblast cultures. in the future, prove useful in limiting excessive collagen deposition in scleroderma and other forms of dermal fibrosis.


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