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bradykinin uses on hypertension drugs

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bradykinin uses on hypertension drugs

Post  sherryfu on Wed Apr 14, 2010 2:22 am

Bradykinin is a physiologically and pharmacologically active peptide of the kinin group of proteins, consisting of nine amino acids. Bradykinin is a 9 amino acid peptide chain. The amino acid sequence of bradykinin is: Arg - Pro - Pro - Gly - Phe - Ser - Pro - Phe - Arg. In humans, bradykinin is broken down by three kininases: angiotensin-converting enzyme (ACE), aminopeptidase P (APP), and carboxypeptidase N (CPN), which cleave the 7-8, 1-2, and 8-9 positions, respectively.

Currently, Bradykinin inhibitors (antagonists) are being developed as potential therapies for hereditary angioedema. Icatibant is one such inhibitor. Additional bradykinin inhibitors exist. It has long been known in animal studies that bromelain, a substance obtained from the stems and leaves of the pineapple plant, suppresses trauma-induced swelling caused by the release of bradykinin into the bloodstream and tissues. Other substances that act as bradykinin inhibitors include aloe. And polyphenols, substances found in red wine and green tea.

Where in some instances, use of Bradykinin-related hypertension drugs, also called ACE inhibitors, may cause a chronic dry cough. This is the number one reason why patients discontinue use of ACE inhibitor drugs. Other medications being offered do not cause this reaction, but they are not as effective, and thus only recommended for those with mild hypertension. Unless the cough becomes severe, patients with chronic or severe hypertension may be advised to continue taking ACE inhibitor medications, sometimes in lowered dosages.


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