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the information of Erlotinib Hydrochloride

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the information of Erlotinib Hydrochloride

Post  kokoblue on Mon Apr 26, 2010 1:30 am

Erlotinib Hydrochloride inhibits the intracellular phosphorylation of tyrosine kinase associated with the epidermal growth factor receptor. It is used for the management of locally advanced or metastatic non-small cell lung cancer that is unresponsive to other therapy. It is also used with gemcitabine in the first-line treatment of patients with locally advanced, unresectable, or metastatic pancreatic cancer.
Recently ,Erlotinib-HCl has been shown to be a potent inhibitor of JAK2V617F activity. JAK2V617F is a mutant of tyrosine kinase JAK2, is found in most patients with polycythemia vera (PV) and a substantial proportion of patients with idiopathic myelofibrosis or essential thrombocythemia. The study suggests that erlotinib may be used for treatment of JAK2V617F-positive PV and other myeloproliferative disorders.

Erlotinib-HClreversibly binds to the ATP-binding site and completely inhibits autophosphorylation epidermal growth factor receptor-tyrosine kinase. This results in blockage of downstream epidermal growth factor receptor signal transduction pathways, cell cycle arrest, and inhibition of angiogenesis.


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