Wikipedia
Search Wikipedia:

September 2017
MonTueWedThuFriSatSun
    123
45678910
11121314151617
18192021222324
252627282930 

Calendar Calendar

Free Hit Counter

the information of Erlotinib Hydrochloride

View previous topic View next topic Go down

the information of Erlotinib Hydrochloride

Post  kokoblue on Mon Apr 26, 2010 1:30 am

Erlotinib Hydrochloride inhibits the intracellular phosphorylation of tyrosine kinase associated with the epidermal growth factor receptor. It is used for the management of locally advanced or metastatic non-small cell lung cancer that is unresponsive to other therapy. It is also used with gemcitabine in the first-line treatment of patients with locally advanced, unresectable, or metastatic pancreatic cancer.
Recently ,Erlotinib-HCl has been shown to be a potent inhibitor of JAK2V617F activity. JAK2V617F is a mutant of tyrosine kinase JAK2, is found in most patients with polycythemia vera (PV) and a substantial proportion of patients with idiopathic myelofibrosis or essential thrombocythemia. The study suggests that erlotinib may be used for treatment of JAK2V617F-positive PV and other myeloproliferative disorders.

Erlotinib-HClreversibly binds to the ATP-binding site and completely inhibits autophosphorylation epidermal growth factor receptor-tyrosine kinase. This results in blockage of downstream epidermal growth factor receptor signal transduction pathways, cell cycle arrest, and inhibition of angiogenesis.

kokoblue

Posts : 15
Join date : 2010-04-21

View user profile

Back to top Go down

View previous topic View next topic Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum