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Stability of aqueous solutions of Amoxicillin sodium

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Stability of aqueous solutions of Amoxicillin sodium

Post  sherryfu on Tue Jul 06, 2010 2:25 am

The comparison between unirradiated and irradiated amoxicillin sodium, performed within 24 h following the irradiation process, showed no significant increase in the pre-existing impurities and no evidence of newly induced degradation products. On the contrary, an appreciable increase in the content of some impurities was evidenced 30 days after the irradiation. Amoxicillin sodium is unstable in aqueous solutions stored between 0 degrees C and -20 degrees C. If admixtures of this drug are to be frozen for later use, the storage temperature should be below -30 degrees C. The combination of amoxicillin, a bactericidal penicillin antibiotic with a broad spectrum of activity, and clavulanic acid, an irreversible beta-lactamase inhibitor forming stable, inactive complexes with the enzymes, thereby protecting amoxicillin from degradation, possesses a broad spectrum of activity.

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Re: Stability of aqueous solutions of Amoxicillin sodium

Post  albertwilson on Mon Jul 19, 2010 5:43 am

The stability of aqueous admixtures of amoxicillin sodium in both the liquid and frozen (solid) states was studied. Admixtures of amoxicillin sodium were prepared in sterile water for injection to a theoretical concentration of 10 mg/ml. For each experimental run, 2-mL aliquots of the admixture were placed in stoppered glass volumetric flasks and stored at temperatures ranging from 19.5 degrees C to -30 degrees C; 16 flasks were stored at each temperature. After equilibration for approximately 20 minutes, duplicate flasks at each temperature were removed from storage conditions for time-zero assay. Subsequently, duplicate flasks were assayed at various times, depending on the storage temperature, for up to 13 days or until more than 80% of the drug had degraded.

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