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Medical applications of sodium thiosulfate

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Medical applications of sodium thiosulfate

Post  gill on Mon Nov 08, 2010 3:33 am


Sodium thiosulfate, also spelled sodium thiosulphate, is a colorless crystalline compound that is more familiar as the pentahydrate, Na2S2O3•5H2O, an efflorescent, monoclinic crystalline substance also called sodium hyposulfite or “hypo.”Sodium thiosulfate is used as an antidote to cyanide poisoning. Thiosulfate acts as a sulfur donor for the conversion for cyanide to thiocyanate, catalyzed by the enzyme rhodanase.It has also been used as treatment of calciphylaxis in hemodialysis patients with end-stage renal disease.Sodium thiosulfate is used in the management of extravasations during chemotherapy. Sodium thiosulfate prevents alkylation and tissue destruction by providing a substrate for the alkylating agents that have invaded the subcutaneous tisuses. The dose may be 2mL of 0.17M. It may be instilled subcutaneously into multiple sites using a small gauge needle. There is limited data on this method with few recommendations. In foot baths for prophylaxis of ringworm, Sodium thiosulfate as a topical antifungal agent for tinea versicolor .in measuring the volume of extracellular body fluid and the renal glomerular filtration rate.


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Sodium Thiosulphate : one of important use

Post  jyoti on Fri Nov 12, 2010 11:23 am

Sodium Thiosulfate is also known or spelled as Sodium Thiosulphate. Its chemical formula is Na2S2O3.
In general organic chemistry it can be used for gold extraction as it can form complex.

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