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The basic information of Sapienic acid

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The basic information of Sapienic acid

Post  gill on Thu Dec 02, 2010 9:56 pm

Sapienic acid is a fatty acid that is a major component of human sebum. Among hair-bearing animals, sapienic acid is unique to humans (thus sapien is the root of its name). The equivalent fatty acid in mouse sebum is palmitoleic acid. Sapienic acid has been implicated in the development of acne, and it may have potent antibacterial activity.
Delta 6 desaturation of palmitic acid leads to the biosynthesis of sapienic acid. In other tissues linoleic acid is the target for delta 6 desaturase, but linoleic acid is degraded in sebaceous cells, allowing the enzyme to desaturate palmitic to sapienic acid. A two-carbon extension product of sapienic acid, sebaleic acid, is also present in sebum.


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