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Uses of Podophyllotoxin(CAS NO.: 518-28-5)

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Uses of Podophyllotoxin(CAS NO.: 518-28-5)

Post  xiaohua on Mon Aug 01, 2011 10:13 pm

The Podophyllotoxin, with CAS registry number 518-28-5, belongs to the following product categories: (1)Plant Oils, Toxins, Phenolic Acids & Derivatives; (2)Natural Plant Extract; (3)Microtobule Inhibitors; (4)Cancer Research; (5)Microtubule Inhibitors; (6)Antitumor Agents; (7)Cell Signaling and Neuroscience; (8)Cytoskeleton and Extracellular Matrix. It has the systematic name of (5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one. This chemical is a kind of off-white fine crystalline powder. And it should be stored at the temperature of 2-8°C. This chemical is exciting leads for anti-tumor agent. For instance, podophyllotoxin is the pharmacological precursor for the important anticancer drug etoposide. It is also used as a gel or solution to treat genital warts with noticeably shorter duration and fewer side effects.

Podophyllotoxin can be used to produce 4-deoxypicropodophyllin. This reaction will need reagent H2 and solvent acetic acid. The reaction time is 24 hour(s). The yield is about 88%.

When you are using Podophyllotoxi, please be cautious about it as the following:
The Podophyllotoxin irritates to eyes, respiratory system and skin. This chemical is harmful in contact with skin. And it is toxic by inhalation, in contact with skin and if swallowed. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

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